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KMID : 0032220080200040260
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Annals of Dermatology
2008 Volume.20 No. 4 p.260 ~ p.262
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Toxic Epidermal Necrolysis Induced by the Topical Carbonic Anhydrase Inhibitors Brinzolamide and Dorzolamide
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Chun Ji-Sun
Yun Sook-Jung
Lee Jee-Bum
Kim Seong-Jin
Won Young-Ho
Lee Seung-Chul
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Abstract
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Brinzolamide and dorzolamide are highly specific topical carbonic anhydrase inhibitors (CAIs). They lower intraocular pressure (IOP) by reducing the rate of aqueous humour formation without serious side effects. Although systemic CAIs are the most potent medications for lowering intraocular pressure for conditions with ocular hypertension, many cases with adverse systemic reactions have been reported, including Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN). Here, we report 2 cases of TEN that were associated with topical CAIs rather than systemic CAIs.
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KEYWORD
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Brinzolamide, Dorzolamide, Toxic epidermal necrolysis
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